Benzalkonium chloride (Alkyldimethylbenzylammonium chloride) |
| Katalog-Nr.GC33931 |
Benzalkoniumchlorid (Alkyldimethylbenzylammoniumchlorid) ist ein starkes antimikrobielles Mittel, das als Konservierungsmittel in Augentropfen verwendet wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 8001-54-5
Sample solution is provided at 25 µL, 10mM.
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Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops.
Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1].
Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1].
[1]. Johnson NF. Pulmonary Toxicity of Benzalkonium Chloride. J Aerosol Med Pulm Drug Deliv. 2017 Jul 6.
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