PAO-Nap |
| Katalog-Nr.GC61552 |
PAO-Nap ist das modifizierte PAO, an das ein Naphthalimid-Fluorophor unter Verwendung von AminocapronsÄure als Linker gebunden ist. PAO induziert durch oxidativen Stress vermittelte Apoptose in HL-60-Zellen, indem es selektiv auf Thioredoxinreduktase abzielt.
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Cas No.: 1613402-20-2
Sample solution is provided at 25 µL, 10mM.
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PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].
PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].
[1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.
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