Boc-NH-PEG4-CH2CH2COOH |
| Katalog-Nr.GC60655 |
Boc-NH-PEG4-CH2CH2COOH ist ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTAC verwendet werden kann. Boc-NH-PEG4-CH2CH2COOH ist auch ein spaltbarer ADC-Linker, der als Linker fÜr AntikÖrper-Wirkstoff-Konjugate (ADC) verwendet wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 756525-91-4
Sample solution is provided at 25 µL, 10mM.
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Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1. [2]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.
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