Bromazolam |
| Katalog-Nr.GC42980 |
Bromazolam ist ein Triazolobenzodiazepin, bekannt als Forschungschemikalie XLI-268.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 71368-80-4
Sample solution is provided at 25 µL, 10mM.
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Bromazolam is a triazolobenzodiazepine that is known as research chemical XLI-268[1]. Bromazolam is structurally similar to alprazolam but is the bromo rather than the chloro analog[2]. Bromazolam metabolites were identified in pHLS9 incubation[3].Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD),It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines.Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81nM at the α1 subtype, 0.69nM at α2 and 0.62nM at α5.
References:
[1]: PubChem. 8-Bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine. pubchem.ncbi.nlm.nih.gov website. Accessed August 18, 2021. https://pubchem.ncbi.nlm.nih.gov/compound/12562546
[2]: McDermott S, Johnson BE, Balasanova AA. Phenibut and Bromazolam Use Disorders Requiring Hospitalization for Medically Supervised Withdrawal. Prim Care Companion CNS Disord. 2022 Jul 12;24(4):21cr03119. doi: 10.4088/PCC.21cr03119. PMID: 35830740.
[3]: Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR. Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam. J Anal Toxicol. 2021 Nov 9;45(9):1014-1027. doi: 10.1093/jat/bkaa161. PMID: 33048135.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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