CAM-IN-1 |
| Katalog-Nr.GC31703 |
CAM-IN-1 ist ein potenter und selektiver Inhibitor von E-Selectin und ICAM-1 mit IC50-Werten von 7 bzw. 5 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 251994-14-6
Sample solution is provided at 25 µL, 10mM.
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CAM-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.
CAM-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. CAM-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with CAM-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed[1].
[1]. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.
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