Camrelizumab (Synonyms: SHR-1210) |
| Katalog-Nr.GC62253 |
Camrelizumab (SHR-1210) ist ein potenter humanisierter monoklonaler IgG4-κ-AntikÖrper (mAb) mit hoher AffinitÄt gegen PD-1. Camrelizumab bindet PD-1 mit einer hohen AffinitÄt von 3 nM und hemmt die Bindungswechselwirkung von PD-1 und PD-L1 mit einem IC50 von 0,70 nM. Camrelizumab wirkt als Anti-PD-1/PD-L1-Wirkstoff und kann fÜr die Krebsforschung verwendet werden, einschließlich NSCLC, ESCC, Hodgkin-Lymphom und fortgeschrittenem HCC et al.
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Cas No.: 1798286-48-2
Sample solution is provided at 25 µL, 10mM.
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Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al[1][2].
In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC50 of 0.38 nM[2].
Camrelizumab (3 mg/kg) combines with apatinib (200 and 100 mg/kg) inhibits the tumor inhibition rates reached 63.1% and 87.3%, respectively in human PD-1 transgenic mice[1].
[1]. Kuimin Mei, et al. Camrelizumab in combination with apatinib in second-line or above therapy for advanced primary liver cancer: cohort A report in a multicenter phase Ib/II trial. J Immunother Cancer. 2021 Mar;9(3):e002191.
[2]. Jason D Lickliter, et al.A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia. Drug Des Devel Ther
[3]. Caicun Zho, et al.Camrelizumab plus carboplatin and pemetrexed versus chemotherapy alone in chemotherapy-naive patients with advanced non-squamous non-small-cell lung cancer (CameL): a randomised, open-label, multicentre, phase 3 trial. Lancet Respir Med. 2021 Mar;9(3):305-314.
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