Canakinumab (Synonyms: Ilaris; ACZ 885) |
| Katalog-Nr.GC66328 |
Canakinumab (ACZ885) ist ein rekombinanter humaner Anti-IL-1β monoklonaler AntikÖrper. Canakinumab zeigt IC50-Werte von 43,6 bzw. 40,8 pM fÜr IL-1&7#946 des Menschen und WeißbÜschelaffen. Die Wirkungsweise von Canakinumab beruht auf der Neutralisierung von IL-1β Signalisierung, was zu einer UnterdrÜckung von EntzÜndungen im Zusammenhang mit StÖrungen autoimmunen Ursprungs fÜhrt.
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Cas No.: 914613-48-2
Sample solution is provided at 25 µL, 10mM.
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IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2]
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].
Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2].Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2].
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