APX-115 free base (Synonyms: Ewha-18278 free base) |
| Katalog-Nr.GC38115 |
Die freie Base APX-115 (freie Base Ewha-18278) ist ein potenter, oral aktiver Pan-Inhibitor der NADPH-Oxidase (Nox) mit Ki-Werten von 1,08 μM, 0,57 μM und 0,63 μM fÜr Nox1, Nox2 bzw. Nox4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1270084-92-8
Sample solution is provided at 25 µL, 10mM.
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APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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