THPP-1 |
| Katalog-Nr.GC39453 |
THPP-1, eine chemische SGC-Sonde, ist ein potenter und oral bioverfÜgbarer Phosphodiesterase 10A (PDE10A)-Hemmer mit Ki-Werten von 1 nM und 1,3 nM fÜr menschliches bzw. Ratten-PDE10A.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1257051-63-0
Sample solution is provided at 25 µL, 10mM.
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THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species[1].
[1]. Smith SM, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology. 2013 Jan;64:215-23. [2]. Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity. Psychopharmacology (Berl). 2016 Jul;233(13):2441-50.
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