UPGL00004 |
| Katalog-Nr.GC61365 |
UPGL00004 ist ein potenter allosterischer Glutaminase C (GAC)-Inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 hemmt stark die Proliferation hochaggressiver dreifach negativer Brustkrebszelllinien.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1890169-95-5
Sample solution is provided at 25 µL, 10mM.
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UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].
UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1].
The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model[1].
[1]. Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545.
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