Panamesine (Synonyms: EMD 57445) |
| Katalog-Nr.GC61926 |
Panamesin (EMD 57445) ist ein Sigma-Rezeptor-Ligand, der eine hohe AffinitÄt (IC50 6 nM) und SelektivitÄt fÜr Sigma-Bindungsstellen aufweist.
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Cas No.: 139225-22-2
Sample solution is provided at 25 µL, 10mM.
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Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1].
Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex[1].
References:
[1]. N Dahmen, et al. Induction of C-Fos Gene Expression by the Selective Sigma Receptor Ligand EMD 57445 in Rat Brain. Eur Neuropsychopharmacol. 1996 Aug;6(3):237-43.
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