7β,27-dihydroxy Cholesterol (Synonyms: 7β,27-DHC) |
| Katalog-Nr.GC46740 |
An oxysterol and agonist of RORγ and RORγt
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 240129-43-5
Sample solution is provided at 25 µL, 10mM.
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7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naÏve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .
Reference:
[1].Soroosh, P., Wu, J., Xue, X., et al.Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiationProc. Natl. Acad. Sci. USA111(33)12163-12168(2014)
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