Aranciamycin (Synonyms: NSC 369226) |
| Katalog-Nr.GC46878 |
A fungal metabolite with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72389-06-1
Sample solution is provided at 25 µL, 10mM.
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Aranciamycin is a fungal metabolite that has been found in Streptomyces and has diverse biological activities.1,2 It inhibits C. histolyticum collagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37, >10, and >10 µM, respectively).1 Aranciamycin is active against M. bovis and B. subtilis (MICs = 30 and 15 µM, respectively).2 It is cytotoxic to HepG2 cells (IC50 = 18 µM).
1.Bols, M., Biderup, L., Hansen, J., et al.Inhibition of collagenase by aranciamycin and aranciamycin derivativesJ. Med. Chem.35(15)1768-2771(1992) 2.Khalil, Z.G., Raju, R., Piggott, A.M., et al.Aranciamycins I and J, antimycobacterial anthracyclines from an Australian marine-derived Streptomyces spJ. Nat. Prod.78(4)949-952(2015)
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