AZ9482 |
| Katalog-Nr.GC46900 |
AZ9482 ist ein dreifacher PARP1/2/6-Inhibitor mit IC50-Werten von 1 nM, 1 nM und 640 nM fÜr PARP1, PARP2 bzw. PARP6.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1825345-33-2
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively).1 It induces centrosome declustering (EC50 = <18 nM) and a multipolar spindle phenotype in HeLa cells. AZ9482 inhibits the growth of OCI-LY19 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 3 nM).
1.Johannes, J.W., Almeida, L., Daly, K., et al.Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clusteringBioorg. Med. Chem. Lett.25(24)5743-5747(2015)
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *