Estetrol (hydrate) (Synonyms: E4, 15α-Hydroxyestriol) |
| Katalog-Nr.GC47309 |
A naturally occurring estrogen
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).1,2 In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.1,2
1.Coelingh Bennink, H.J.T., Holinka, C.F., and Diczfalusy, E.Estetrol review: Profile and potential clinical applicationsClimacteric.11(Suppl 1)47-58(2008) 2.Giretti, M.S., Guevara, M.M.M., Cecchi, E., et al.Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin CytoskeletonFront.Endocrinol.(Lausanne)5(80)1-8(2014)
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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