PAF C-16-d4 (Synonyms: Plateletactivating Factor C16d4)

PAF C-16-d₄ contains four deuterium atoms at the 7, 7', 8, and 8' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.¹ It is a potent mediator of neutrophil migration,² the production of reactive oxygen species,³ and IL-6⁴ in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-18⁵. Pathological processes involving PAF include necrotizing enterocolitis,⁶ inflammation, asthma, and allergy.⁷

1.Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorThe Journal of Biological Chemisty26517381-17384(1990) 2.Carolan, E.J., and Casale, T.B.Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular speciesJournal of Immunology1452561-2565(1990) 3.Rouis, M., Nigon, F., and Chapman, M.J.Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophagesBiochemical and Biophysical Research Communications1561293-1301(1988) 4.Thivierge, M., and Rola-Pleszczynski, M.Platelet-activating factor enhances interleukin-6 production by alveolar macrophagesJournal of Allergy and Clinical Immunology90796-802(1992) 5.Stewart, A.G., and Grigoriadis, G.Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophagesJournal of Lipid Mediators4299-308(1991) 6.Wang, H., Tan, X.D., Qu, X.W., et al.Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximidePediatric Research42597-603(1997) 7.Sturk, A., Wouter Ten Cate, J., Hosford, D., et al.The synthesis, catabolism, and pathophysiological role of platelet-activating factorAdvances in Lipid Research23219-276(1989)