Sporogen-AO 1 (Synonyms: (+)-Sporogen-AO 1)

Sporogen-AO 1 is a fungal metabolite originally isolated from A. oryzae that has diverse biological activities.^1,2,3,4,5 It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC₅₀ value of 15.8 µM.⁴ Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC₅₀s = 8.3, 9, and 5.1 µM, respectively).^2,5 It is active against C. albicans (MIC = 4 mM).³

1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(51)5907-5910(1984) 2.Motohashi, K., Hashimoto, J., Inaba, S., et al.New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1J. Antibiot. (Tokyo)62(5)247-250(2009) 3.Yurchenko, A., Smetanina, O.F., Kalinovsky, A., et al.Biologically active metabolites of the facultative marine fungus Penicillium citrinumChem. Nat. Compd.48(6)996-998(2013) 4.Jayasuriya, H., Zink, D.L., Polishook, J.D., et al.Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivationChem. Biodivers.2(1)112-122(2005) 5.Tansakul, C., Rukachaisirikul, V., Chalothorn, T., et al.Synthesis and cytotoxicity against KB and NCI-H187 cell lines of sporogen AO-1 analoguesPhytochem. Lett.22128-132(2017)