BPKDi |
| Katalog-Nr.GC48620 |
BPKDi ist ein potenter Bipyridyl-PKD-Inhibitor mit IC50-Werten von 1 nM, 9 nM und 1 nM fÜr PKD1, PKD2 bzw. PKD3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1201673-28-0
Sample solution is provided at 25 µL, 10mM.
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BPKDi is an inhibitor of protein kinase D (PKD; IC50s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively).1 It is selective for PKD over PKCδ and PKCε, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 µM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 µM.
1.Monovich, L., Vega, R.B., Meredith, E., et al.A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinaseFEBS Lett.584(3)631-637(2010)
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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