1-Hydroxyanthraquinone (Synonyms: NSC 8640) |
| Katalog-Nr.GC48909 |
1-Hydroxyanthrachinon, eine natÜrlich vorkommende Verbindung mit oraler Wirkung aus einigen Pflanzen wie Tabebuia avellanedae, weist eine krebserzeugende Wirkung auf.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 129-43-1
Sample solution is provided at 25 µL, 10mM.
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1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities.1,2 1-Hydroxyanthraquinone (5 and 500 µM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.1 Dietary administration of 1-hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.
1.Kawai, K., Mori, H., Sugie, S., et al.Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinonesCell Biol. Toxicol.2(4)457-467(1986) 2.Mori, H., Yoshimi, N., Iwata, H., et al.Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasmsCarcinogenesis11(5)799-802(1990)
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