Tauro-α-muricholic Acid-d4 (sodium salt) (Synonyms: Tauro-β-muricholate-d4, TβMCA-d4) |
| Katalog-Nr.GC49011 |
An internal standard for the quantification of tauro-α-muricholic acid
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Tauro-α-muricholic acid-d4 (TαMCA-d4) is intended for use as an internal standard for the quantification of TαMCA by GC- or LC-MS. TαMCA is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1 TαMCA is common in rodents but has also been found in small amounts in human serum.2
1.Sayin, S.I., WahlstrÖm, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013) 2.GarcÍa-CaÑaveras, J.C., Donato, M.T., Castell, J.V., et al.Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated methodJ. Lipid Res.53(10)2231-2241(2012)
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