DL-threo-β-Hydroxyaspartic Acid (Synonyms: DL-THA, DL-threo-3-Hydroxyaspartic Acid) |
| Katalog-Nr.GC49829 |
An EAAT inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4294-45-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
DL-threo-β-Hydroxyaspartic acid is an inhibitor of excitatory amino acid transporters (EAATs).1,2 It inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s = 96 and 31 µM, respectively) as well as inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 0.6 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 2.5 µM) voltage-clamped at -60 mV. Intrathecal administration of DL-threo-β-hydroxyaspartic acid (7.5 and 15 µg/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats.3
1.Shimamoto, K., Lebrun, B., Yasuda-Kamatani, Y., et al.??-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.Mol. Pharmacol.53(2)195-201(1998) 2.Shigeri, Y., Shimamoto, K., Yasuda-Kamatani, Y., et al.Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)J. Neurochem.79(2)297-302(2001) 3.Yaster, M., Guan, X., Petralia, R.S., et al.Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund’s adjuvantAnesthesiology114(2)412-423(2011)
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *