3’-Azido-2’,3’-dideoxyuridine (Synonyms: AZddU, AZU, Navuridine, NSC 380882) |
| Katalog-Nr.GC49871 |
An antiviral nucleoside analog
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 84472-85-5
Sample solution is provided at 25 µL, 10mM.
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3’-Azido-2’,3’-dideoxyuridine (AZddU) is an antiviral nucleoside analog.1 It is phosphorylated by thymidine kinase.2 AZddU inhibits cytopathogenicity induced by HIV or Moloney sarcoma virus (MSV) in MT-4 cells (EC50s = 0.36 and 15 µM, respectively).1
1.Balzarini, J., Baba, M., Pauwels, R., et al.Anti-retrovirus activity of 3’-fluoro- and 3’-azido-substituted pyrimidine 2’,3’-dideoxynucleoside analoguesBiochem. Pharmacol.37(14)2847-2856(1988) 2.Eriksson, B.F., Chu, C.K., and Schinazi, R.F.Phosphorylation of 3’-azido-2’,3’-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5’-triphosphateAntimicrob. Agents Chemother.33(10)1729-1734(1989)
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