Balicatib (Synonyms: AAE581) |
| Katalog-Nr.GC12751 |
Balicatib (AAE581) ist ein potenter, oral aktiver und selektiver Cathepsin-K-Inhibitor mit IC50-Werten von 22, 61, 48, 2900 nM fÜr Cathepsin K, Cathepsin B, Cathepsin L bzw. Cathepsin S.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 354813-19-7
Sample solution is provided at 25 µL, 10mM.
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Balicatib is an inhibitor of cathepsin K with IC50 value of 1.4nM [1].
Balicatib is highly selective against cathepsin K over cathepsin B, L and S in the in vitro enzyme assay. However, the selectivity is not so high in cell-based enzyme assay. The lysosomotropic character of balicatib results in its accumulation in lysosomes and the subsequent nonselective off-target effects. The off-target effects also cause the skin adverse events of balicatib [1, 2].
As a cathepsin K inhibitor, balicatib is developed for osteoporosis. It has been reported to reduce the biochemical markers of bone resorption and increase bone mineral density in ovariectomized monkeys. In addition, balicatib shows benefits in new bone formation of postmenopausal women [2].
References:
[1] Black WC. Peptidomimetic inhibitors of cathepsin K. 2010;10(7):745-51.
[2] Brömme D, Lecaille F. Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opin Investig Drugs. 2009 May;18(5):585-600.
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