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- GC41185 MAGL Inhibitor Compound 23 MAGL Inhibitor Compound 23 ist ein potenter, selektiver, reversibler und kompetitiver Inhibitor von MAGL mit einem IC50 von 80 nM. MAGL Inhibitor Compound 23 zeigt antiproliferative Wirkungen gegen menschliche Brust-, Darm- und Eierstockkrebszellen. MAGL Inhibitor Compound 23 blockiert MAGL sowohl in zellbasierten als auch in vivo-Assays.
- GC44501 Oleoyl Oxazolopyridine Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide.
- GC44482 O-Arachidonoyl Glycidol 2-Arachidonoyl glycerol (2-AG) is an endogenous ligand that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity.
- GC44481 O-7460 O-7460 ist ein potenter und selektiver DAGLα-Inhibitor mit einem IC50-Wert von 0,69 μM.
- GC44340 N-Cyclohexanecarbonyltetradecylamine Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids.
- GC44339 N-Cyclohexanecarbonylpentadecylamine Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids.
- GC44049 LEI-106 LEI-106 ist ein potenter, dualer sn-1-Diacylglycerol-Lipase-α (DAGL-α)/ABHD6-Inhibitor mit einem IC50 von 18 nM fÜr DAGL-α und einem Ki von 0,8 μM fÜr ABHD6.
- GC44015 KT109 N2 Regioisomer KT109 N2 regioisomer is an N2-carbamoylated regioisomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC44014 KT109 KT109 ist ein potenter und isoformselektiver Inhibitor der Diacylglycerollipase-β (DAGLβ) mit einem IC50 von 42 nM.
- GC43935 JW 618 Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors.
- GC43928 JJH260 JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs).
- GC43918 Isopropyl dodec-11-enylfluorophosphonate Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).
- GC43891 IDFP The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2).
- GC43148 CAY10401 Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide.
- GC42668 ABC34 ABC34 is an inactive control probe for JJH260, the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs).
- GC41925 15(S)-HETE Ethanolamide Arachidonoyl ethanolamide was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC.
- GC41738 (S)-KT109 (S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC41718 (R)-KT109 (R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC41599 URB754 URB754 ist ein potenter Inhibitor des Endocannabinoid-deaktivierenden Enzyms Monoacylglycerol-Lipase (MGL) mit einem IC50 von 200 nM.
- GC40955 PHOP Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide.
- GC40864 JP104 The enzyme, fatty acid amide hydrolase (FAAH), is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.
- GC40821 CAY10435 Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide.