CCR7 Ligand 1 (Synonyms: CCR7-Cmp2105) |
| Katalog-Nr.GC39356 |
CCR7-Ligand 1 (CCR7-Cmp2105) ist ein allosterischer Ligand und Antagonist fÜr den humanen CC-Chemokinrezeptor 7 (CCR7) mit einer Kd von 3 nM. CCR7 Ligand 1, Thiadiazoldioxidligan, unterdrÜckt die Arrestinbindung als Reaktion auf die Aktivierung durch CCL19 mit einem IC50 von 7,3 μM.
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Cas No.: 681514-83-0
Sample solution is provided at 25 µL, 10mM.
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CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].
[1]. Jaeger K, et al. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell. 2019 Aug 22;178(5):1222-1230.e10.
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