Cerivastatin (sodium salt) (Synonyms: BAY-w 6228) |
| Katalog-Nr.GC43231 |
Cerivastatin (Natriumsalz) ist ein synthetischer Lipidsenker und ein hochpotenter, gut vertrÄglicher und oral aktiver HMG-CoA-Reduktase-Hemmer mit einem Ki von 1,3 nM/L.
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Cas No.: 143201-11-0
Sample solution is provided at 25 µL, 10mM.
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Cerivastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (Ki = 1.3 nM). It inhibits cholesterol synthesis in and growth of human arterial myocytes (IC50s = 0.4 and 4.6 nM, respectively). Cerivastatin inhibits proliferation of rat aorta smooth muscle cells and reduces fibrogen-induced migration of rat aortic myocytes in a concentration-dependent manner. In vivo, cerivastatin inhibits cholesterol biosynthesis in rats and dogs (ED50 = 0.002 mg/kg for both). It reduces serum levels of cholesterol, triglycerides, and low-density lipoprotein (LDL) in dogs in a dose-dependent manner. Cerivastatin (0.1 mg/kg) decreases cholesterol ester accumulation in arterial tissue of rabbits fed a 0.2% cholesterol diet. It also stabilizes plaques and delays progression into atherosclerotic disease in LDL-receptor deficient rabbits with hypercholesterolemia.
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