Chloramphenicol succinate sodium |
| Katalog-Nr.GC39661 |
Chloramphenicolsuccinat-Natrium ist ein Prodrug von Chloramphenicol mit HÄmatotoxizitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 982-57-0
Sample solution is provided at 25 µL, 10mM.
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Chloramphenicol succinate sodium is a prodrug of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity[1][2][3].
[1]. Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9(3):222-38. [2]. Ambekar CS, et al. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicol In Vitro. 2004 Aug;18(4):441-7. [3]. Turton JA, et al. Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Hum Exp Toxicol. 1999 Sep;18(9):566-76.
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