Chlorpyrifos |
| Katalog-Nr.GC60108 |
Chlorpyrifos ist ein Organophosphat-Insektizid, das als Phosphorothionat eingestuft wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2921-88-2
Sample solution is provided at 25 µL, 10mM.
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Chlorpyrifos, as a broad-spectrum organophosphorothioate insecticide, has a principal mechanism of toxicity by inactivation of acetylcholinesterase at nerve junctions[1].
In vitro test it exhibited that In agricultural soils under field conditions,half-lives are shorter. The mean water-soil adsorption coefficient(Koc) of chlorpyrifos is 8,216 mL/g[2]. The 24-h LC10 and LC50 values of chlorpyrifos for embryos were 0.89 and 11.8 µg/L, respectively. And the 24-h LC10 and LC50 values of chlorpyrifos for larvae were 0.53 and 21.7 µg/L, respectively; the 48-h LC10 and LC50 for larvae were 0.04 and 5.47 µg/L, respectively. Moreover, in the aquatic environment ,1 µg/L of chlorpyrifos may adversely affect the development and the reproduction of banded gourami[3].
In vivo efficacy test it shown that there is a similar sensitivity to orally administered chlorpyrifos with LD50s ranging from 8 to > 400 mg/kg body weight in amphibians, birds, and mammals. There is also no observed effect concentrations to be greater than 1 mg/kg food in long-term chronic feeding studies in birds and mammals[1]. In addition, the exposure to environmentally relevant chlorpyrifos with 0.03, 0.06 and 0.12 µg/L increased precopulatory guardian behavior time, amplexus reformulation after exposure and the number of ovigerous females in the amphipod Hyalella curvispina[4]. Exposure to 500 µg/L chlorpyrifos for 15 days, there is no consistent obvious effect in both male and female gonado-somatic index[5].
References:
[1] Barron MG, et al. Ecotoxicology of chlorpyrifos. Rev Environ Contam Toxicol. 1995;144:1-93.
[2] Solomon KR, et al. Properties and uses of chlorpyrifos in the United States. Rev Environ Contam Toxicol. 2014;231:13-34.
[3] Sumon KA, et al. Acute toxicity of chlorpyrifos to embryo and larvae of banded gourami Trichogaster fasciata. J Environ Sci Health B. 2017 Feb;52(2):92-98.
[4] Negro CL, et al. Effects of Chlorpyrifos Over Reproductive Traits of Three Sympatric Freshwater Crustaceans. Bull Environ Contam Toxicol. 2021 May;106(5):759-764.
[5] Sumon KA, et al. Effects of long-term chlorpyrifos exposure on mortality and reproductive tissues of Banded Gourami (Trichogaster fasciata). J Environ Sci Health B. 2019;54(7):549-559.
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