1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (Synonyms: 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA) |
Katalog-Nr.GC41825
One-Click Copy Product Info
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1,2-Dipalmitoyl-sn-glycero-3-phosphat (Natriumsalz) (Verbindung 3-F7) ist eine PhosphatidsÄure und ein menschlicher endogener Metabolit[1]In Vitro: PhosphatidsÄuren sind biologisch aktive Lipide, die eine große Bandbreite stimulieren kÖnnen von Reaktionen in vielen verschiedenen Zelltypen, wie Thrombozytenaggregation, Kontraktion glatter Muskeln, vasoaktive Wirkungen in vivo, Chemotaxis, Expression von AdhÄsionsmolekÜlen, erhÖhte Tight-Junction-PermeabilitÄt von Endothelzellen, Induktion von Stressfasern, Modulation der HerzkontraktilitÄt und viele andere .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 169051-60-9
Sample solution is provided at 25 µL, 10mM.
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1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (16:0/16:0-PA) is a phospholipid containing long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions, which can be used to prepare liposomes, micelles and artificial membranes[1, 2]. During retinoic acid and serum starvation-induced neuronal differentiation, diacylglycerol kinase z (DGKz) in mouse neuroblastoma Neuro-2a cells can specifically produce 1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]. 1,2-Dipalmitoyl-sn-glycero-3-phosphate can bind to α-synuclein (α-syn)[4].
References:
[1] Sierra-Valdez F J, Forero-Quintero L S, Zapata-Morin P A, et al. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers[J]. PLoS One, 2013, 8(4): e59364.
[2] Jing W, Prenner E J, Vogel H J, et al. Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin‐1[J]. Journal of Peptide Science: An Official Publication of the European Peptide Society, 2005, 11(11): 735-743.
[3] Sakane F, Mizuno S, Takahashi D, et al. Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways[J]. Advances in biological regulation, 2018, 67: 101-108.
[4] Mizuno S, Sasai H, Kume A, et al. Dioleoyl‐phosphatidic acid selectively binds to α‐synuclein and strongly induces its aggregation[J]. FEBS letters, 2017, 591(5): 784-791.
| Cas No. | 169051-60-9 | SDF | |
| Überlieferungen | 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA | ||
| Canonical SMILES | CCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP([O-])(O)=O)=O.[Na+] | ||
| Formula | C35H68O8P•Na | M.Wt | 670.9 |
| Löslichkeit | Methanol: 7 mg/mL (ultrasonic and adjust pH to 3 with 1 M HCL) | Storage | Store at 2-8°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4905 mL | 7.4527 mL | 14.9054 mL |
| 5 mM | 298.1 μL | 1.4905 mL | 2.9811 mL |
| 10 mM | 149.1 μL | 745.3 μL | 1.4905 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)