Chrysomycin B (Synonyms: Albacarcin M, Virenomycin M) |
| Katalog-Nr.GC18344 |
Chrysomycin B ist ein aus einem Streptomyces-Stamm isoliertes Antibiotikum. Chrysomycin B verursacht DNA-SchÄden in der Zelllinie des menschlichen Lungenadenokarzinoms A549 und hemmt die Topoisomerase II. Chrysomycin B unterdrÜckt das Wachstum von transplantierbaren Tumoren bei MÄusen.
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Cas No.: 83852-56-6
Sample solution is provided at 25 µL, 10mM.
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Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.
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Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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