CU-CPD107 |
Katalog-Nr.GC25314 |
CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2573912-32-8
Sample solution is provided at 25 µL, 10mM.
CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.
CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1]
[1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351.
Average Rating: 5
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