Cu-GTSM (Synonyms: CuII(gtsm), copper-GTSM) |
Katalog-Nr.GC49557
One-Click Copy Product Info
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A copper-containing compound with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68341-14-0
Sample solution is provided at 25 µL, 10mM.
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Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM that has diverse biological activities.1,2,3,4 It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC50s = 0.3-0.6 µM for all).1 Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC50s = 0.009 and 0.27 µM, respectively).2 It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 µM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model.3 Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimer’s disease.4
1.Haeili, M., Moore, C., Davis, C.J.C., et al.Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureusAntimicrob Agents Chemother.58(7)3727-3736(2014) 2.Stefani, C., Al-Eisawi, Z., Jansson, P.J., et al.Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilizationJ. Inorg. Biochem.15220-37(2015) 3.Cater, M.A., Pearson, H.B., Wolyniec, K., et al.Increasing intracellular bioavailable copper selectively targets prostate cancer cellsACS Chem. Biol.8(7)1621-1631(2013) 4.Torres, J.B., Andreozzi, E.M., Dunn, J.T., et al.PET imaging of copper trafficking in a mouse model of alzheimer diseaseJ. Nucl. Med.57(1)109-114(2016)
| Cas No. | 68341-14-0 | SDF | |
| Überlieferungen | CuII(gtsm), copper-GTSM | ||
| Canonical SMILES | CNC1=N[N]2=CC=[N]3[Cu+2]2([S-]1)[S-]C(NC)=N3 | ||
| Formula | C6H10CuN6S2 | M.Wt | 293.9 |
| Löslichkeit | DMF: 20 mg/mL,DMSO: 10 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.16 mg/mL | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4025 mL | 17.0126 mL | 34.0252 mL |
| 5 mM | 680.5 μL | 3.4025 mL | 6.805 mL |
| 10 mM | 340.3 μL | 1.7013 mL | 3.4025 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)