CX08005 |
| Katalog-Nr.GC50357 |
Competitive PTP1B inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1256341-22-6
Sample solution is provided at 25 µL, 10mM.
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Competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 173 1939 PMID:26990621
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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