DCLX069 |
Katalog-Nr.GC63662 |
DCLX069 ist ein selektiver Protein-Arginin-Methyltransferase-1 (PRMT1)-Inhibitor mit einem IC50-Wert von 17,9 μM. DCLX069 zeigt weniger AktivitÄt gegenÜber PRMT4 und PRMT6. DCLX069 hat Antikrebswirkungen.
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Cas No.: 792946-69-1
Sample solution is provided at 25 µL, 10mM.
DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1].
DCLX069 (12.5-100 µM) effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid leukemia cell lines (MCF7, HepG2, and THP1 cells) in a concentration-dependent manner[1].
[1]. Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org Biomol Chem. 2014 Dec 21;12(47):9665-73.
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