DI-1859 |
| Katalog-Nr.GC65576 |
DI-1859 ist ein potenter, selektiver und kovalenter Inhibitor von DCN1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2247061-09-0
Sample solution is provided at 25 µL, 10mM.
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DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage[1].
[1]. Zhou H, et al. Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nat Commun. 2021;12(1):2621.
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