E7766 disodium |
| Katalog-Nr.GC62609 |
E7766 Dinatrium ist ein Makrocyclus-verbrÜckter STING-Agonist mit einem Kd von 40 nM. E7766 Dinatrium zeigt starke pangenotypische und AntitumoraktivitÄten.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2242636-28-6
Sample solution is provided at 25 µL, 10mM.
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E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].
E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].
In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].
[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.
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