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Endovion (Synonyms: NS3728)

Katalog-Nr.GC34574

Endovion (NS3728) ist ein pharmakologischer Anionenkanal-Inhibitor (wie Chloridkanal) und der spezifische VRAC/VSOAC-Blocker.

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Endovion Chemische Struktur

Cas No.: 265646-85-3

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5mg
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10mg
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2]. Chloride channel, VRAC/VSOAC[1]. ANO1[2].

[1]. S?rensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. [2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.

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