Estramustine |
| Katalog-Nr.GC67333 |
Estramustin ist ein antineoplastisches Mittel. Estramustin depolymerisiert Mikrotubuli durch Bindung an Tubulin 1, zeigt antimitotische Aktivität mit einem IC50-Wert von ~16 μ M für die Mitose von DU 145-Zellen. Estramustin blockiert Zellen bei der Mitose in Prostatatumor-Xenotransplantaten.
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Cas No.: 2998-57-4
Sample solution is provided at 25 µL, 10mM.
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Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].
[1]. DahllÖf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53(19):4573-81.
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