Eupenifeldin |
| Katalog-Nr.GC43643 |
Eupenifeldin ist ein pentazyklisches Bistropolon, das aus Kulturen von Eupenicillium brefeldianum ATCC 74184 isoliert wurde. Eupenifeldin ist zytotoxisch gegenÜber der HCT-116-Zelllinie. Eupenifeldin hat das Potenzial fÜr die Erforschung von LeukÄmie.
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Cas No.: 151803-45-1
Sample solution is provided at 25 µL, 10mM.
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Eupenifeldin is a pentacyclic bistropolone fungal metabolite originally isolated from E. brefeldianum ATCC 74184. It is cytotoxic against HCT116 and HCTVM46 colon carcinoma cells in vitro (IC50s = 0.005 and 0.002 μg/ml, respectively). In vivo, eupenifeldin (0.3-2 mg/kg per day) increases median survival time in a mouse model of P388 leukemia.
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