FIIN 1 hydrochloride (Synonyms: FGFR irreversible inhibitor-1) |
| Katalog-Nr.GC50051 |
FIIN 1-Hydrochlorid ist ein potenter, irreversibler, selektiver FGFR-Inhibitor. FIIN 1-Hydrochlorid bindet an FGFR1/2/3/4 und Flt1/4 mit Kds von 2,8/6,9/5,4/120 nM bzw. 32/120 nM. Die biochemischen IC50-Werte von FIIN-1-Hydrochlorid sind 9,2, 6,2, 11,9 bzw. 189 nM gegen FGFR1/2/3/4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1256152-35-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074.
Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285 PMID:20338520
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *