Dehydroeffusol |
| Katalog-Nr.GC35834 |
Dehydroeffusol ist ein Phenanthren aus dem Heilkraut Juncus effuses. Dehydroeffusol hemmt das Wachstum und die TumorigenitÄt von Magenkrebszellen, indem es selektiv tumorunterdrÜckenden Stress des endoplasmatischen Retikulums und eine moderate Apoptose induziert. Es zeigt eine sehr geringe ToxizitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137319-34-7
Sample solution is provided at 25 µL, 10mM.
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Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].
Dehydroeffusol suppresses the expression of vasculogenic mimicry key gene VE-cadherin[2].Dehydroeffusol decreases the MMP2 expression and activity in gastric cancer cells[2].
[1]. Zhang B, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016 Mar 15;104:8-18. [2]. Liu W, et al. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):98-110.
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