PI3Kγ inhibitor 1 |
Katalog-Nr.GC36910 |
PI3Kγ Inhibitor 1 ist ein PI3Kδ- und PI3Kγ-Inhibitor, extrahiert aus Patent WO2014004470A1, Verbindung 168 in Tabelle 4, hat IC50s von \u003c 100 nM.
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Cas No.: 1172118-03-4
Sample solution is provided at 25 µL, 10mM.
PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM. PI3Kδ|100 nM (IC50)|PI3Kγ|100 nM (IC50)|PI3Kα|10 μM (IC50)|PI3Kβ|10 μM (IC50)
In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of <100 nM, <100 nM, <10 μM and <10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC50<100 nM.
[1]. Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.
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