ROR agonist-1 |
Katalog-Nr.GC37556 |
ROR-Agonist-1 ist ein potenter und oral bioverfÜgbarer inverser Agonist des RetinsÄurerezeptor-verwandten Orphan-Rezeptors C2 (RORC2), der die IL-17A-Produktion aus humanen primÄren TH 17-Zellen mit einem pIC50 von 7,5 hemmt.
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Cas No.: 2361528-74-5
Sample solution is provided at 25 µL, 10mM.
ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1]. pIC 50: 7.5 (human primary TH 17 cells)[1]
[1]. von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10(6):972-977.
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