WR99210 (Synonyms: BRL 6231 free base) |
| Katalog-Nr.GC37938 |
WR99210 ist ein oral aktiver Dihydrofolatreduktase (DHFR)-Hemmer mit geringer ToxizitÄt (IC50<0,075 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 47326-86-3
Sample solution is provided at 25 µL, 10mM.
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WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of Plasmodium falciparum strains[2]. IC50: <0.075 nM (DHFR)[1]
[1]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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