Groenlandicine |
| Katalog-Nr.GC38511 |
Groenlandicin ist ein aus Coptidis Rhizoma isoliertes Protoberberin-Alkaloid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 38691-95-1
Sample solution is provided at 25 µL, 10mM.
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Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].
[1]. Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12. [2]. Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.
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