Lofepramine |
| Katalog-Nr.GC38533 |
A tricyclic antidepressant
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 23047-25-8
Sample solution is provided at 25 µL, 10mM.
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Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].
[1]. Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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