Demethylwedelolactone (Synonyms: DWL, Norwedelolactone, 1,3,8,9-Tetrahydroxycoumestan) |
| Katalog-Nr.GC38576 |
Demethylwedelolacton ist ein natÜrlich vorkommendes Coumestan, das aus Eclipta alba isoliert wird. Demethylwedelolacton ist ein potenter Trypsin-Inhibitor mit einem IC50 von 3,0 μM. Demethylwedelolacton unterdrÜckt die ZellmotilitÄt und die Zellinvasion von Brustkrebszellen.
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Cas No.: 6468-55-9
Sample solution is provided at 25 µL, 10mM.
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Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell[1][2].
[1]. Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. 2003 Apr;17(4):420-1. [2]. Lee YJ, et al. Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur J Med Chem. 2012 Oct;56:361-7.
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