Fraxinol |
| Katalog-Nr.GC45457 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 486-28-2
Sample solution is provided at 25 µL, 10mM.
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Fraxinol is a coumarin originally isolated from Ash tree bark.1 It inhibits growth of GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells (IC50s = 193 and 165 μM, respectively).2 Fraxinol potentiates barbiturate-induced sleep in rats and rabbits.3
References
1. Spath, E., and Jerzmanowska-Sienkiewiczowa, Z. Natural coumarins. XXV. Fraxinol, a new constituent of the bark of the ash. Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 70B, 698-702 (1937).
2. Kolodziej, H., Kayser, O., Woerdenbag, H.J., et al. Structure-cytotoxicity relationships of a series of natural and semi-synthetic simple coumarins as assessed in two human tumour cell lines. Z. Naturforsch. C 52(3-4), 240-244 (1997).
3. Khadzhai, Y.I. Effect of coumarin, flavonoid, and khellin derivatives on the soporific effect of barbiturates. Farmakologiya i Toksikologiya (Kiev) 7, 46-48 (1972).
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