Glycolithocholic Acid 3-sulfate (sodium salt) (Synonyms: Lithocholylglycine 3-sulfate, 3-Sulfoglycolithocholic Acid, Sulfolithocholylglycine) |
| Katalog-Nr.GC49701 |
Ein Metabolit der Glykolithocholsäure.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64936-82-9
Sample solution is provided at 25 µL, 10mM.
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Glycolithocholic acid 3-sulfate is a metabolite of glycolithocholic acid .1 It is formed from glycolithocholic acid by hepatocytes.2Glycolithocholic acid 3-sulfate (240 µmol/kg) induces cholestasis and increases biliary cholesterol secretion in rats.3 Serum glycolithocholic acid 3-sulfate levels are increased in patients with cirrhosis, hepatitis, or cholestasis.4
References:
1.Palmer, R.H.The formation of bile acid sulfates: A new pathway of bile acid metabolism in humansProc. Natl. Acad. Sci. USA58(3)1047-1050(1967)
2.Kirkpatrick, R.B., and Belsaas, R.A.Formation and secretion of glycolithocholate-3-sulfate in primary hepatocyte culturesJ. Lipid Res.26(12)1431-1437(1985)
3.Yousef, I.M., Tuchweber, B., Vonk, R.J., et al.Lithocholate cholestasis-sulfated glycolithocholate-induced intrahepatic cholestasis in ratsGastroenterology80(2)233-241(1981)
4.Demers, L.M., and Hepner, G.W.Levels of immunoreactive glycine-conjugated bile acids in health and hepatobiliary diseaseAm. J. Clin. Pathol.66(5)831-839(1976)
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