GNE 9278 |
| Katalog-Nr.GC50433 |
Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 901230-11-3
Sample solution is provided at 25 µL, 10mM.
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Positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.
Wang et al (2017) A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 121 204 PMID:28457974
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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